hSORT1/4T1
CBPG0268
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| I. Background | |||
| SORT1基因编码Sortilin蛋白，是VPS10相关Sortilin家族的重要成员，在细胞内主要扮演“分拣受体”的角色。它的核心功能是将特定蛋白质从高尔基体精确转运至溶酶体、内体或细胞表面，同时还能与proBDNF等关键分子结合，介导神经元凋亡等信号传导过程。在临床层面，SORT1基因的表达水平与血液中低密度脂蛋白胆固醇（LDL-C）浓度及心肌梗死患病风险显著相关，是脂质代谢和心血管疾病研究中的重要关注点。 | |||
| II. Introduction | |||
| Host Cell: | 4T1 | ||
| Expressed gene: | hSORT1 | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | RPMI-1640+10%FBS+ 2μg/ml Puromycin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mouse | ||
| Tissue: | Mammary gland | ||
| Morphology: | Epithelial | ||
| Growth Properties: | Adherent | ||
IV. Representative Data Figure 1.Recombinant hSORT1/4T1 stably expressing hSORT1. |
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